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Amir Ardeshir Lab

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Determinants of successful AAV-vectored delivery of HIV-1 bNAbs in early life
After 30 years of failed attempts to deliver HIV antibodies via gene therapy, we discovered the solution was timing—specifically, the...
Amir Ardeshir
Jul 30, 20251 min read
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Gates Foundation funds new Durable Medicine Model Unit
Tulane received nearly $1 million from the Gates Foundation to establish the Durable Medicine Model Unit at TNBRC, with Amir Ardeshir as unit leader.
Amir Ardeshir
Dec 12, 20251 min read
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HIV research highlighted during State of the University address
President Michael A. Fitts delivered his State of the University address at TNBRC, citing the finding that a single shot at birth could offer years of protection against HIV.
Amir Ardeshir
Dec 12, 20251 min read
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Nature: one dose at birth, years of protection in infant macaque models of HIV transmission
A single AAV dose at birth sustained 3BNC117 expression in infant rhesus macaques for more than three years and protected against mucosal SHIV challenge.
Amir Ardeshir
Jul 30, 20251 min read
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Same Precision, Quarter the Work Through Statistical Computing in COVID-19 Histopathology
Evaluating COVID-19 lung damage in rhesus macaques requires examining thousands of microscopic fields—a process that can take weeks per...
Amir Ardeshir
Jun 25, 20251 min read
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SciDiscover: advancing molecular research with AI
SciDiscover is an open-source computational framework that integrates language models with scientific knowledge bases to analyze molecular mechanisms and pathways.
Amir Ardeshir
Mar 9, 20251 min read
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Beyond CD4+ Counts: Galectin-9 as a Superior Predictor of HIV Disease Progression
This study reveals plasma galectin-9 as a superior biomarker for predicting HIV/SIV disease progression compared to the traditional CD4+...
Amir Ardeshir
Mar 5, 20251 min read
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Beyond Receptor Binding: Unexpected Mechanisms of HIV Resistance to eCD4-Ig
This study documents the first evidence of HIV envelope evolution conferring resistance to eCD4-Ig, a promising entry inhibitor that...
Amir Ardeshir
Mar 5, 20251 min read
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Bridging Immunology and Metabolism: The Critical Role of CD Molecules in Metabolic Syndrome
This pioneering review bridges immunology and metabolism by systematically examining how cluster of differentiation (CD) molecules...
Amir Ardeshir
Mar 5, 20251 min read
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Immune Activation Biomarkers Transcend Specific HIV Comorbidities
Our groundbreaking study reveals that galectin-3, galectin-9, and IL-18 function primarily as indicators of systemic immune dysfunction...
Amir Ardeshir
Mar 5, 20251 min read
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Editorial: The early life window of opportunity: role of the microbiome on immune system imprinting
We curated a collection of cutting-edge research examining how the early-life microbiome shapes immune system development with lifelong...
Amir Ardeshir
Mar 5, 20251 min read
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