Nature: one dose at birth, years of protection in infant macaque models of HIV transmission
Jul 30, 2025
1 min read
Our study "Determinants of successful AAV-vectored delivery of HIV-1 bNAbs in early life" was published in Nature.
A single administration at birth of an AAV vector encoding the broadly neutralizing antibody 3BNC117 sustained antibody expression in infant rhesus macaques for more than three years without redosing, and protected infant and pre-adolescent animals against mucosal SHIV challenge in models of both breastfeeding and sexual transmission.
Age at dosing was the main determinant of success, inversely correlated with host anti-drug antibodies.
The study was also covered in outlets in seven other languages.
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