Bridging Immunology and Metabolism: The Critical Role of CD Molecules in Metabolic Syndrome

This pioneering review bridges immunology and metabolism by systematically examining how cluster of differentiation (CD) molecules contribute to metabolic syndrome pathogenesis. While metabolic syndrome affects millions globally, its underlying mechanisms have remained elusive. Our comprehensive analysis reveals how specific CD molecules—crucial immune system markers—mediate key pathological processes including adipose tissue inflammation, insulin resistance, dyslipidemia, and hypertension. We demonstrate that immune dysregulation isn't merely associated with metabolic dysfunction but actively drives it through specific molecular pathways. By identifying the precise immune markers involved in each aspect of metabolic syndrome, our work establishes a framework for developing targeted therapeutics that address the root immunological causes rather than just managing symptoms. This paradigm-shifting approach opens new avenues for treating a condition previously viewed primarily through a metabolic rather than immunological lens.

Title: Cluster of differentiation molecules in the metabolic syndrome

https://doi.org/10.1016/j.cca.2024.119819